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New Downstream Processing Zone


Client: Serono S A
Location: Aubonne, Switzerland
Completion: 1997
Scope of Work: Front End Design Packages, Engineering, Procurement and Validation
Project Value: £16 Million (Total DSP 4 and USP 4 Projects)

Downstream Processing Suite 4 for purification and concentration of fermented bulk hormone products involving multiple chromatography, ultrafiltration/ diafiltration and virus removal steps.
 


Downstream Processing


Features

  • Demolition of existing area with only internal perimeter walls and structural concrete remaining 
  • Protection of operational areas during construction of new proprietary clean room system 
  • Air handling systems helicopter lifted onto roof and constructed in place 
  • Upgraded existing site chilled water capacity including new 70 cu.m buffer tank within 6 hour shutdown 
  • Purified water, clean steam, heating water, chilled water and gases modified by installing new tie ins to existing services 
  • New 180 kW -10 deg C glycol chiller system to serve DSP 4 and future production centre 
  • Areas designed for operation at Grades C & D including double wall construction for clean rooms against external walls  
  • Fully automated buffer preparation room with equipment for materials additions installed under clean conditions 
  • Fully classified Grade C & D ventilated cold rooms 
  • 100% fresh air air handling unit systems with terminal HEPA filters on supply and provision for terminal HEPA filters on the extract 
  • Lead engineers based on site to develop facility design with Client and liaise with contractors on design and selection of components and materials available in Switzerland 
  • Site supervision and co-ordination personnel resident on site for construction, commissioning and validation activitieswere members of design team.

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