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New Downstream Processing Zone
Client: Serono S A Location: Aubonne, Switzerland Completion: 1997 Scope of Work: Front End Design Packages, Engineering, Procurement and Validation Project Value: £16 Million (Total DSP 4 and USP 4 Projects)
Downstream Processing Suite 4 for purification and concentration of fermented bulk hormone products involving multiple chromatography, ultrafiltration/ diafiltration and virus removal steps.
Contact 

+44 (0)1489 614422 | 

+1 908 429 9100 |
RELEVANT INFORMATION 

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Features
- Demolition of existing area with only internal perimeter walls and structural concrete remaining
- Protection of operational areas during construction of new proprietary clean room system
- Air handling systems helicopter lifted onto roof and constructed in place
- Upgraded existing site chilled water capacity including new 70 cu.m buffer tank within 6 hour shutdown
- Purified water, clean steam, heating water, chilled water and gases modified by installing new tie ins to existing services
- New 180 kW -10 deg C glycol chiller system to serve DSP 4 and future production centre
- Areas designed for operation at Grades C & D including double wall construction for clean rooms against external walls
- Fully automated buffer preparation room with equipment for materials additions installed under clean conditions
- Fully classified Grade C & D ventilated cold rooms
- 100% fresh air air handling unit systems with terminal HEPA filters on supply and provision for terminal HEPA filters on the extract
- Lead engineers based on site to develop facility design with Client and liaise with contractors on design and selection of components and materials available in Switzerland
- Site supervision and co-ordination personnel resident on site for construction, commissioning and validation activitieswere members of design team.
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