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New Upsteam Processing Zone
Client: Laboratoires Serono S A
Location: Aubonne, Switzerland
Completion: 1996
Scope of Work: Front End Design Packages, Engineering, Procurement Construction Co-ordination and Validation
Project Value: £16 Million (Total DSP 4 & USP 4 Projects)
Upstream Processing Suite 4 scaled up process from 11 litre to 30 litre fermentations using multiple bioreactors
Contact 
+44 (0)1489 614422 |
+1 908 429 9100 |
RELEVANT INFORMATION
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Features
- Existing area completely remodelled for new process equipment with all other services tied back and re-routed within ceiling void
- Facilities for manufacture of hormone products based on genetically modified organisms
- Multiple microcarrier fermentation facility based on perfusion technology including utilities and media distribution system
- Modification of existing envelope with adjacent ares operational
- Extension of existing utilities systems to serve new process equipment
- Modification of existing 100% fresh air handling system with modification for increased pressure control
- Designed for operation at Grade D EU GMP
- Design development based in Switzerland
- Extended front end designs bid by Swiss contractors, bid analysis and selection by AKpharmaceuticals and Client
- Site based co-ordination and engineering personnel provided for construction and validation activities were same enginers that carried out design activities
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